Epilepsy and electroencephalographic abnormalities in patients with diagnosis of idiopathic autism spectrum disorder in Medellín
Authors
Angélica Arteaga
Perfil Google Scholar
Elizabeth Vélez
William Cornejo
Rodrigo Solarte
Angélica Lobo
Verónica Jaramillo
Julissa Otero
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Arteaga, A. ., Vélez, E. ., Cornejo, W. ., Solarte, R. ., Lobo, A. ., Jaramillo, V. ., & Otero, J. . (2021). Epilepsy and electroencephalographic abnormalities in patients with diagnosis of idiopathic autism spectrum disorder in Medellín. International Journal of Psychological Research, 14(1), 115–120. https://doi.org/10.21500/20112084.5335
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To give up copyright, the authors allow that, International Journal of Psychological Research, distribute the work more broadly, check for the reuse by others and take care of the necessary procedures for the registration and administration of copyright; at the same time, our editorial board represents the interests of the author and allows authors to re-use his work in various forms. In response to the above, authors transfer copyright to the journal, International Journal of Psychological Research. This transfer does not imply other rights which are not those of authorship (for example those that concern about patents). Likewise, preserves the authors rights to use the work integral or partially in lectures, books and courses, as well as make copies for educational purposes. Finally, the authors may use freely the tables and figures in its future work, wherever make explicit reference to the previous publication in International Journal of Psychological Research. The assignment of copyright includes both virtual rights and forms of the article to allow the editorial to disseminate the work in the manner which it deems appropriate.
The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.
Abstract
The objective of the present study was to make a clinical and electroencephalographic characterization of the electrical findings and types of seizures in patients with idiopathic autism. Pediatric patients of any age, with the diagnosis of idiopathic ASD, contained within the database of the research “Genetic in autism” were included. An electroencephalographic recording with epilepsy protocol was performed in all the patients. 20 pediatric patients were included with an age media of 10.5 years, SD 5.48 years. The median age for the diagnosis of ASD was 53 months, and epileptic seizures were documented in 45%. 66.6% of patients with epileptic events had anti-epileptic treatment, and only 33.3% had achieved seizure control with medication. Interictal abnormal EEG records were found in 8 patients (40%), with 6 of them having epileptic seizures. The abnormal EEG activity was multifocal in 62.5%, focal in 25% and generalized in 12.5% of the cases. The most frequently compromised location was the temporal lobe.
References
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Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, Electroencephalographic Abnormalities, and Regression in Children with Autism. Centers for Disease Control and Prevention. (2016). Autism Spectrum Disorder Data & Statistics. https://www.cdc.gov/ncbddd/autism/data.html.
Christelle, M., Achkar, E., & Spence, S. J. (2015). Clinical characteristics of children and young adults with co-occurring autism spectrum disorder and epilepsy. Epilepsy & behavior: E&B, 47, 183–190.https://doi.org/10.1016/j.yebeh.2014.12.022.
Christensen, J., Overgaard, M., Partner, E. T., Vertergaard, M., & Schendel, D. (2016). Risk of epilepsy and autism in full and half siblings –A population–based cohort study. Epilepsia, 57 (12), 2011–2018. https://doi.org/10.1111/epi.13595.
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Fombonne, E. (2005). Developing modern child psychiatry. World psychiatry: official journal of the World Psychiatric Association, 4 (3), 156–157.
Gabis, L., Pomeroy, J., & Andriola, M. R. (2005). Autism and epilepsy: Cause, consequence, comorbidity, or coincidence? Epilepsy & behavior: E&B, 7 (4), 652–656. https://doi.org/10.1016/j.yebeh.2005.08.
Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., Havlovicova, M., Sedlacek, Z., Blatny, M., & Urbanek, T. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European child & adolescent psychiatry, 13 (4), 209–213. https://doi.org/10.1007/s00787-004-0353-.
Hutt, S. J., Hutt, C., Lee, D., & Ounsted, C. (1965). A behavioural and electroencephalographic study of autistic children. Journal of psychiatric research, 3 (3), 181–197. https://doi.org/10.1016/0022-3956(65)90028-.
Johnson, C. P., Myers, S. M., & American Academy of Pediatrics Council on Children with Disabilities. (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120 (5), 1183–1215. https://doi.org/10.1542/peds.2007-.
Jokiranta, E., Sourander, A., Suominen, A., Timonen- Soivio, L., Brown, A. S., & Sillanpää, M. (2014). Epilepsy among children and adolescents with autism spectrum disorders: A population-based study. Journal of autism and developmental disorders, 44 (10), 2547–2557. https://doi.org/10.1007/s10803-014-2126-.
Lai, M. C., Lombardo, M. V., Auyeung, B., Chakrabarti, B., & Baron-Cohen, S. (2015). Sex/gender differences and autism: Setting the scene for future research. Journal of the American Academy of Child and Adolescent Psychiatry, 54 (1), 11–24. https://doi.org/10.1016/j.jaac.2014.10.003.
Lukmanji, S., Manji, S. A., Kadhim, S., Sauro, K. M., Wirrell, E. C., Kwon, C. S., & Jetté, N. (2019). The co-occurrence of epilepsy and autism: A systematic review. Epilepsy & behavior: E&B, 98, 238–248. https://doi.org/10.1016/j.yebeh.2019.07.
Matson, J. L., Beighley, J., & Turygin, N. (2012). Autism diagnosis and screening: Factors to consider in differential diagnosis. Research in Autism Spectrum Disorders, 6 (1), 19–24. https://doi.org/10.1016/j.rasd.2011.08.003.
Mottron, L., Belleville, S., Rouleau, G. A., & Collignon, O. (2014). Linking neocortical, cognitive, and genetic variability in autism with alterations of brain plasticity: the Trigger-Threshold-Target model. Neuroscience and biobehavioral reviews, 47, 735–752. https://doi.org/10.1016/j.neubiorev.2014.07.012.
Nicotera, A. G., Hagerman, R. J., Catania, M. V., Buono, S., Di Nuovo, S., Liprino, E. M., Stracuzzi, E., Giusto, S., Di Vita, G., & Musumeci, S. A. (2019). EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study. Journal of autism and developmental disorders, 49 (6), 2337–2347.
Olsson, I., Steffenburg, S., & Gillberg, C. (1988). Epilepsy in autism and autisticlike conditions. A population- based study. Archives of neurology, 45 (6), 666–668. https://doi.org/10.1001/archneur.1988.00520300086024.
Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L., Constantino, J. N., Dobkins, K., Hutman, T., Iverson, J. M., Landa, R., Rogers, S. J., Sigman, M., & Stone, W. L. (2011). Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics, 128 (3), e488–e495. https://doi.org/10.1542/peds.2010-2825.
Parmeggiani, A., Barcia, J., Posar, A., Raimondi, M., E.and Santucci, & C., S. M. (2010). Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders. Brain and Development, 32 (9), 783–789. https://doi.org/10.1016/j.braindev.2010.07.003.
Portnova, G. V., Mcglone, F. P., Tankina, O. A., Skorokhodov, I. V., Shpitsberg, I. L., & Varlamov, A. A. (2019). EEG Correlates of Tactile Perception Abnormalities in Children with Autism Spectrum Disorder. Modern technologies in medicine, 11 (1 (eng)), 169–174. https://doi: 10.17691/stm2019.11.1.20.
Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995). EEG features and epilepsy in patients with autism. Brain & development, 17 (3), 169–174. https://doi.org/10.1016/0387-7604(95)00019-8.
Sansa, G., Carlson, C., Doyle, W., Weiner, H. L., Bluvstein, J., Barr, W., & Devinsky, O. (2011). Medically refractory epilepsy in autism. Epilepsia, 52 (6), 1071–1075. https://doi.org/10.1111/j.1528-1167.2011.03069.x.
Shattuck, P. T., Durkin, M., Maenner, M., Newschaffer, C., Mandell, D. S., Wiggins, L., Lee, L. C., Rice, C., Giarelli, E., Kirby, R., Baio, J., Pinto-Martin, J., & Cuniff, C. (2009). Timing of identification among children with an autism spectrum disorder: Findingsfromapopulation-based surveillance study. Journal of the American Academy of Child and Adolescent Psychiatry, 48 (5), 474–483. https://doi.org/10.1097/CHI.0b013e31819b3848.
Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric research, 65 (6), 599–606. https://doi.org/10.1203/PDR.0b013e31819e7168.
Tuchman, R., Moshé, S. L., & Rapin, I. (2009). Convulsing toward the pathophysiology of autism. Brain & development, 31 (2), 95–103. https://doi.org/10.1016/j.braindev.2008.09.009.
Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99 (4), 560–566. https://doi.org/ 10.1542/peds.99.4.560.
Wirrell, E., Wong-Kisiel, L., Payne, E., & Nickels, K. (2017). Risk factors, prevalence and impact of comorbid autism in pediatric epilepsy: A population-based study. European Journal of pediatric neurology, 21 (1), 185–186. https://doi.org/10.1016/j.ejpn.2017.04.772.
Wong, V. (1993). Epilepsy in children with autistic spectrum disorder. Journal of child neurology, 8 (4), 316–322. https://doi.org/10.1177/088307389300800405.
Baird, G., Robinson, R. O., Boyd, S., & Charman, T. (2006). Sleep electroencephalograms in young children with autism with regression. Dev Med Child neurol, 48, 604–608.
Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, Electroencephalographic Abnormalities, and Regression in Children with Autism. Centers for Disease Control and Prevention. (2016). Autism Spectrum Disorder Data & Statistics. https://www.cdc.gov/ncbddd/autism/data.html.
Christelle, M., Achkar, E., & Spence, S. J. (2015). Clinical characteristics of children and young adults with co-occurring autism spectrum disorder and epilepsy. Epilepsy & behavior: E&B, 47, 183–190.https://doi.org/10.1016/j.yebeh.2014.12.022.
Christensen, J., Overgaard, M., Partner, E. T., Vertergaard, M., & Schendel, D. (2016). Risk of epilepsy and autism in full and half siblings –A population–based cohort study. Epilepsia, 57 (12), 2011–2018. https://doi.org/10.1111/epi.13595.
Collins, A. L., Ma, D., Whitehead, P. L., Martin, E. R., Wright, H. H., Abramson, R. K., Hussman, J. P., Haines, J. L., Cuccaro, M. L., Gilbert, J. R., & Pericak-Vance, M. A. (2006). Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. Neurogenetics, 7 (3), 167–174. https://doi.org/10.1007/s10048-006-0045-.
Filipek, P. A., Accardo, P. J., Ashwal, S., Baranek, G. T., Cook, E. H. J., Dawson, G., Gordon, B., Gravel, J. S., Johnson, C. P., Kallen, R. J., Levy, S. E., Minshew, N. J., Ozonoff, S., Prizant, B. M., Rapin, I., Rogers, S. J., Stone, W. L., Teplin, S. W., Tuchman, R. F., & Volkmar, F. R. (2000). Practice parameter: screening and diagnosis of autism: report of the Quality Standards Subcommitteeof the American Academy of Neurology and the Child Neurology Society. Neurology, 55 (4), 468–479. https://doi.org/10.1212/wnl.55.4.468.
Fombonne, E. (2005). Developing modern child psychiatry. World psychiatry: official journal of the World Psychiatric Association, 4 (3), 156–157.
Gabis, L., Pomeroy, J., & Andriola, M. R. (2005). Autism and epilepsy: Cause, consequence, comorbidity, or coincidence? Epilepsy & behavior: E&B, 7 (4), 652–656. https://doi.org/10.1016/j.yebeh.2005.08.
Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., Havlovicova, M., Sedlacek, Z., Blatny, M., & Urbanek, T. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European child & adolescent psychiatry, 13 (4), 209–213. https://doi.org/10.1007/s00787-004-0353-.
Hutt, S. J., Hutt, C., Lee, D., & Ounsted, C. (1965). A behavioural and electroencephalographic study of autistic children. Journal of psychiatric research, 3 (3), 181–197. https://doi.org/10.1016/0022-3956(65)90028-.
Johnson, C. P., Myers, S. M., & American Academy of Pediatrics Council on Children with Disabilities. (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120 (5), 1183–1215. https://doi.org/10.1542/peds.2007-.
Jokiranta, E., Sourander, A., Suominen, A., Timonen- Soivio, L., Brown, A. S., & Sillanpää, M. (2014). Epilepsy among children and adolescents with autism spectrum disorders: A population-based study. Journal of autism and developmental disorders, 44 (10), 2547–2557. https://doi.org/10.1007/s10803-014-2126-.
Lai, M. C., Lombardo, M. V., Auyeung, B., Chakrabarti, B., & Baron-Cohen, S. (2015). Sex/gender differences and autism: Setting the scene for future research. Journal of the American Academy of Child and Adolescent Psychiatry, 54 (1), 11–24. https://doi.org/10.1016/j.jaac.2014.10.003.
Lukmanji, S., Manji, S. A., Kadhim, S., Sauro, K. M., Wirrell, E. C., Kwon, C. S., & Jetté, N. (2019). The co-occurrence of epilepsy and autism: A systematic review. Epilepsy & behavior: E&B, 98, 238–248. https://doi.org/10.1016/j.yebeh.2019.07.
Matson, J. L., Beighley, J., & Turygin, N. (2012). Autism diagnosis and screening: Factors to consider in differential diagnosis. Research in Autism Spectrum Disorders, 6 (1), 19–24. https://doi.org/10.1016/j.rasd.2011.08.003.
Mottron, L., Belleville, S., Rouleau, G. A., & Collignon, O. (2014). Linking neocortical, cognitive, and genetic variability in autism with alterations of brain plasticity: the Trigger-Threshold-Target model. Neuroscience and biobehavioral reviews, 47, 735–752. https://doi.org/10.1016/j.neubiorev.2014.07.012.
Nicotera, A. G., Hagerman, R. J., Catania, M. V., Buono, S., Di Nuovo, S., Liprino, E. M., Stracuzzi, E., Giusto, S., Di Vita, G., & Musumeci, S. A. (2019). EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study. Journal of autism and developmental disorders, 49 (6), 2337–2347.
Olsson, I., Steffenburg, S., & Gillberg, C. (1988). Epilepsy in autism and autisticlike conditions. A population- based study. Archives of neurology, 45 (6), 666–668. https://doi.org/10.1001/archneur.1988.00520300086024.
Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L., Constantino, J. N., Dobkins, K., Hutman, T., Iverson, J. M., Landa, R., Rogers, S. J., Sigman, M., & Stone, W. L. (2011). Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics, 128 (3), e488–e495. https://doi.org/10.1542/peds.2010-2825.
Parmeggiani, A., Barcia, J., Posar, A., Raimondi, M., E.and Santucci, & C., S. M. (2010). Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders. Brain and Development, 32 (9), 783–789. https://doi.org/10.1016/j.braindev.2010.07.003.
Portnova, G. V., Mcglone, F. P., Tankina, O. A., Skorokhodov, I. V., Shpitsberg, I. L., & Varlamov, A. A. (2019). EEG Correlates of Tactile Perception Abnormalities in Children with Autism Spectrum Disorder. Modern technologies in medicine, 11 (1 (eng)), 169–174. https://doi: 10.17691/stm2019.11.1.20.
Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995). EEG features and epilepsy in patients with autism. Brain & development, 17 (3), 169–174. https://doi.org/10.1016/0387-7604(95)00019-8.
Sansa, G., Carlson, C., Doyle, W., Weiner, H. L., Bluvstein, J., Barr, W., & Devinsky, O. (2011). Medically refractory epilepsy in autism. Epilepsia, 52 (6), 1071–1075. https://doi.org/10.1111/j.1528-1167.2011.03069.x.
Shattuck, P. T., Durkin, M., Maenner, M., Newschaffer, C., Mandell, D. S., Wiggins, L., Lee, L. C., Rice, C., Giarelli, E., Kirby, R., Baio, J., Pinto-Martin, J., & Cuniff, C. (2009). Timing of identification among children with an autism spectrum disorder: Findingsfromapopulation-based surveillance study. Journal of the American Academy of Child and Adolescent Psychiatry, 48 (5), 474–483. https://doi.org/10.1097/CHI.0b013e31819b3848.
Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric research, 65 (6), 599–606. https://doi.org/10.1203/PDR.0b013e31819e7168.
Tuchman, R., Moshé, S. L., & Rapin, I. (2009). Convulsing toward the pathophysiology of autism. Brain & development, 31 (2), 95–103. https://doi.org/10.1016/j.braindev.2008.09.009.
Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99 (4), 560–566. https://doi.org/ 10.1542/peds.99.4.560.
Wirrell, E., Wong-Kisiel, L., Payne, E., & Nickels, K. (2017). Risk factors, prevalence and impact of comorbid autism in pediatric epilepsy: A population-based study. European Journal of pediatric neurology, 21 (1), 185–186. https://doi.org/10.1016/j.ejpn.2017.04.772.
Wong, V. (1993). Epilepsy in children with autistic spectrum disorder. Journal of child neurology, 8 (4), 316–322. https://doi.org/10.1177/088307389300800405.
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