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T Mendoza, E., Villada, M., & Velasquez Martinez, M. C. (2024). Voluntary Ethanol Intake and Anxiety Behavior in Wistar-Uis Rats. International Journal of Psychological Research, 17(1), 63–72.
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Ethanol consumption is among the first five substances with higher risk associated with diseases, disability, and death in the world. Anxiety behavior has been linked to ethanol-addictive conduct. The aim of the present study
was to evaluate three strains with differential anxiety behavior: a Wild-type strain; a “Reactive” strain, with an increase in anxiety-related behaviors; and a “Non-Reactive” strain, with lower anxiety-related behaviors, before and
after the voluntary consumption of ethanol (10%) protocol. To evaluate anxiety, animals were exposed to the elevated plus-maze 24 h before and after the consumption protocol. On the voluntary consumption of ethanol protocol, the animals were exposed to a water and an ethanol bottle. The
weight of the liquid consumed daily for 40 days was registered. Results: all strains increased ethanol vs water consumption: Wild-type: day 8; R: day 10; NR: day 31. Ethanol consumption reduced the number and percentage
of open arms entries only on the Wild-type strain. Conclusion: anxiety can predispose to an increase in ethanol consumption and to the maintenance of
anxiety-related behaviors.



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