Neurofunctional areas related to food appetency in anorexia nervosa


Anorexia Nervosa
food appetency

How to Cite

Cervantes-Navarrete, J. J., Alcauter-Solórzano, S., Miguel-Bueno, C., Gonzalez-Olvera, J. J., Carrillo-Mezo, R., Martínez-Gudiño, M. de L., & Caballero-Romo, A. de J. (2012). Neurofunctional areas related to food appetency in anorexia nervosa. International Journal of Psychological Research, 5(2), 91–97.


In Anorexia Nervosa the observable phenomenon is the suppression of appetite. Little is known about the biological and psychological (top-down) bases that maintain this pathological state. However, Anorexia Nervosa is a biological, psychological and social model where the main behavioral characteristic is the inhibition of eating behavior; not by bottom-up but top-down regulation. Objective: To explore the areas of the brain associated with food appetency through functional magnetic resonance in women with anorexia nervosa. Methods: The subjects include 5 female with Restrictive type of Anorexia Nervosa and five controls female with similar in age and low weigh. The subjects were within the MRI scanner and while took fMRI they saw food images that would generate appetite. The subjects were in fasting state and mentally prepare by instruction “imagine you are eating the food presented in the following images”. Results: Compared differences in the activation between subjects four regions were found significant: the anterior cingulate, left front medial region and the left and right midbrain. Conclusions: The patients with Anorexia Nervosa present different activated cerebral areas to those of the controls during the visual exposition to food in hungry state and with evoke cognitions associated with eat food; those regions may be implicated in reward and self-control.


Allison, S.& Timmerman, G. M. (2007). Anatomy of a binge: food environment and characteristics of nonpurge binge episodes. Eating Behaviors, 8(1), 31–38. doi:10.1016/j.eatbeh.2005.01.004

American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. American Psychiatric Association.

Barbano, M. F.& Cador, M. (2005). Differential Regulation of the Consummatory, Motivational and Anticipatory Aspects of Feeding Behavior by Dopaminergic and Opioidergic Drugs. Neuropsychopharmacology, 31(7), 1371–1381. doi:10.1038/sj.npp.1300908

Beckmann, C. F., Jenkinson, M.& Smith, S. M. (2003). General multilevel linear modeling for group analysis in FMRI. NeuroImage, 20(2), 1052–1063. doi:10.1016/S1053-8119(03)00435-X

Berthoud, H.-R. (2006). Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance. Obesity (Silver Spring, Md.), 14 Suppl 5, 197S–200S. doi:10.1038/oby.2006.308

Brooks, S. J., O'Daly, O. G., Uher, R., Friederich, H.-C., Giampietro, V., Brammer, M., et al. (2011). Differential neural responses to food images in women with bulimia versus anorexia nervosa. (S. J. Brooks, O. G. O Daly, R. Uher, H.-C. Friederich, V. Giampietro, M. Brammer, et al., Eds.)PLoS ONE, 6(7), e22259. doi:10.1371/journal.pone.0022259.t002

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