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Valencia Piedrahita, M., & Cuartas Arias, J. M. (2016). Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro. International Journal of Psychological Research, 9(1), 98–112. https://doi.org/10.21500/20112084.2105
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To give up copyright, the authors allow that, International Journal of Psychological Research, distribute the work more broadly, check for the reuse by others and take care of the necessary procedures for the registration and administration of copyright; at the same time, our editorial board represents the interests of the author and allows authors to re-use his work in various forms. In response to the above, authors transfer copyright to the journal, International Journal of Psychological Research. This transfer does not imply other rights which are not those of authorship (for example those that concern about patents). Likewise, preserves the authors rights to use the work integral or partially in lectures, books and courses, as well as make copies for educational purposes. Finally, the authors may use freely the tables and figures in its future work, wherever make explicit reference to the previous publication in International Journal of Psychological Research. The assignment of copyright includes both virtual rights and forms of the article to allow the editorial to disseminate the work in the manner which it deems appropriate.
The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.
Resumen
Este artículo de revisión presenta las estrategias más apropiadas para el estudio de endofenotipos en los trastornos de personalidad. Actualmente existen muchos estudios neurobiológicos y moleculares que sugieren una predisposición genética a diferentes rasgos representativos expresados en dichos trastornos. No obstante, la replicación exitosa de tales resultados no ha sido posible, debido a dificultades relacionadas a la sensibilidad, especificidad y validación de los métodos implementados en las evaluaciones clínicas; el tamaño y tipo de poblaciones elegidas, y los diseños experimentales implementados. Desafortunadamente, los diagnósticos hechos en psiquiatría y psicología cuentan con un sistema de clasificación basado en la prevalencia y la intensidad de los síntomas, sin tener en cuenta la etiología, neurobiología, epidemiología, genética y la respuesta a los medicamentos. Por otra parte, explicar la fenomenología de los trastornos de personalidad y como los genes expresan el fenotipo, implica una revisión de la teoría del caos, direccionándola a la conexión entre en neurodesarrollo, eventos estresantes significativos durante la infancia temprana y modificaciones en el ADN asociados a eventos estocásticos que contribuyen al desarrollo de conductas normales y anormales.
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