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Cuartas Arias, J. M. (2011). Psychobiology and candidate endophenotypes in psychopathy. International Journal of Psychological Research, 4(1), 92–101. https://doi.org/10.21500/20112084.804
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The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.
To give up copyright, the authors allow that, International Journal of Psychological Research, distribute the work more broadly, check for the reuse by others and take care of the necessary procedures for the registration and administration of copyright; at the same time, our editorial board represents the interests of the author and allows authors to re-use his work in various forms. In response to the above, authors transfer copyright to the journal, International Journal of Psychological Research. This transfer does not imply other rights which are not those of authorship (for example those that concern about patents). Likewise, preserves the authors rights to use the work integral or partially in lectures, books and courses, as well as make copies for educational purposes. Finally, the authors may use freely the tables and figures in its future work, wherever make explicit reference to the previous publication in International Journal of Psychological Research. The assignment of copyright includes both virtual rights and forms of the article to allow the editorial to disseminate the work in the manner which it deems appropriate.
The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.
Abstract
At present there exist a lot of neurobiological and molecular studies that suggest genetic susceptibility to different characteristics of the expression of psychopathy; nevertheless, so far much of those results have not successfully and consistently been replicated, mainly because of the difficulties in: sensitivity, specificity and validity of the clinical evaluation methods; the size and type of the chosen population; and the experimental designs used. Unfortunately, the diagnoses in psychiatry and psychology uses a classification based on prevalence and intensity of the symptoms and do not taken into account the etiology, neurobiology, epidemiology, genetics and response to medication. The use of limited diagnostic tools analysis and dichotomized the clinical diagnoses lead to a loss of power in the validation of the phenotype being studied and the lack of neurobiological knowledge of the molecules implicated in this kind of disorders, increasing the genetic heterogeneity. This condition obstructs the mapping of susceptibility genes which might outline the neurobiology and pathophysiology of the disease as a central scheme in the conceptualization of the syndrome. This article, we present the most appropriate strategies for examining the phenotype of psychopathy through the use of endophenotypes.
References
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Beaver, K. M. (2011). Genetic influences on being processed through the criminal justice system: results from a sample of adoptees. Biol Psychiatry, 69(3), 282-287.
Berman, M. E., & Coccaro, E. F. (1998). Neurobiologic correlates of violence: relevance to criminal responsibility. Behav Sci Law, 16(3), 303-318.
Bernstein, I. H., & Gesn, P. R. (1997). On the dimensionality of the Buss/Perry Aggression Questionnaire. Behav Res Ther, 35(6), 563-568.
Blair, K. S., Newman, C., Mitchell, D. G., Richell, R. A., Leonard, A., Morton, J., et al. (2006). Differentiating among prefrontal substrates in psychopathy: neuropsychological test findings. Neuropsychology, 20(2), 153-165.
Boutwell, B. B., & Beaver, K. M. (2008). A biosocial explanation of delinquency abstention. Crim Behav Ment Health, 18(1), 59-74.
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