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Tovilla-Zarate, C. A., & Gómez Mendoza, A. D. (2012). Genes, the serotonergic system and suicidal behavior. International Journal of Psychological Research, 5(1), 52–58. https://doi.org/10.21500/20112084.751
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The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.
To give up copyright, the authors allow that, International Journal of Psychological Research, distribute the work more broadly, check for the reuse by others and take care of the necessary procedures for the registration and administration of copyright; at the same time, our editorial board represents the interests of the author and allows authors to re-use his work in various forms. In response to the above, authors transfer copyright to the journal, International Journal of Psychological Research. This transfer does not imply other rights which are not those of authorship (for example those that concern about patents). Likewise, preserves the authors rights to use the work integral or partially in lectures, books and courses, as well as make copies for educational purposes. Finally, the authors may use freely the tables and figures in its future work, wherever make explicit reference to the previous publication in International Journal of Psychological Research. The assignment of copyright includes both virtual rights and forms of the article to allow the editorial to disseminate the work in the manner which it deems appropriate.
The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.
Abstract
The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior.
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References
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Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688(1-2), 121-133.
Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry, 33(10), 1193-1197.
Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: an overview. Harvard of Review Psychiatry, 12(1), 1-13.
Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1976). Classification of suicidal behaviors. II. Dimensions of suicidal intent. Archives of General Psychiatry, 33(7), 835-837.
Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics. Part B Neuropsychiatric Genetics, 124B(1), 87-91.
Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688(1-2), 121-133.
Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry, 33(10), 1193-1197.
Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: an overview. Harvard of Review Psychiatry, 12(1), 1-13.
Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1976). Classification of suicidal behaviors. II. Dimensions of suicidal intent. Archives of General Psychiatry, 33(7), 835-837.
Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics. Part B Neuropsychiatric Genetics, 124B(1), 87-91.
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