Potential interactions between oxytocin receptor system (OXTR) and candidate genes associated to psychopathy
PDF
PDF (Español (España))

Keywords

OXT
OXTR
Oxytocine
Psychopathy
candidate genes
endophenotype

How to Cite

Cuartas Arias, J. M., & López Jaramillo, C. A. (2013). Potential interactions between oxytocin receptor system (OXTR) and candidate genes associated to psychopathy. International Journal of Psychological Research, 6, 109–116. https://doi.org/10.21500/20112084.725

Abstract

Psychopathy is the result of a complex interaction between biological and environmental factors; both participate in the final expression of the phenotype and can modulate the variation regarding beginning, deterioration, and severity. Nevertheless, up to now it has not been possible to determine the circumscribed molecular track and its interaction with environmental factors that shape its expression. However, beyond the progresses regarding diagnostic evaluation, there are some difficulties in the construction of a neurobiological model that contributes to differentiate the antisocial behavior. That is why exploring the molecular-genetic, biochemical and hormonal mechanisms involved in the different neuro-physiological tracks modulated by candidate genes could contribute to determine significantly how the neurobiological findings impact the individual differences in the expression of psychopathy. This article aims to go in depth into those neurobiological mechanisms underlying psychopathy from the expression and regulation of the oxytocinergic system.
https://doi.org/10.21500/20112084.725
PDF
PDF (Español (España))

References

Arias, M. C. (2011). Functional enviromics and personality disorders. International Journal of Psychological Research, 4(2), 5-8.

Aron, A., Ketay, S., Hedden, T., Aron, E. N., Rose Markus, H., & Gabrieli, J. D. (2010). Temperament trait of sensory processing sensitivity moderates cultural differences in neural response. [Research Support, N.I.H., Extramural]. Social cognitive and affective neuroscience, 5(2-3), 219-226. doi: 10.1093/scan/nsq028

Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2013). A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Psychiatric genetics. doi: 10.1097/YPG.0b013e3283643684

Belsky, J. (1997). Variation in susceptibility to rearing influences: an evolutionary argument. PsycholInquiry, 8, 182-186.

Cacioppo, J. T., Cacioppo, S., & Boomsma, D. I. (2013). Evolutionary mechanisms for loneliness. Cognition & emotion. doi: 10.1080/02699931.2013.837379

Caldwell, J. D., Brooks, P. J., Jirikowski, G. F., Barakat, A. S., Lund, P. K., & Pedersen, C. A. (1989). Estrogen alters oxytocin mRNA levels in the preoptic area. Journal of neuroendocrinology, 1(4), 273-278. doi: 10.1111/j.1365-2826.1989.tb00115.x

Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., . . . Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Science, 297(5582), 851-854. doi: 10.1126/science.1072290

Clonniger, C., Rakic, S. y Pezybeckt, D. (1993). A psychobiological model of temperament and character. Archives of General Psychiatric., 50(975-990).

Cordell, H. J., & Clayton, D. G. (2005). Genetic association studies. Lancet, 366(9491), 1121-1131. doi: S0140-6736(05)67424-7 [pii]10.1016/S0140-6736(05)67424-7

Cuartas Arias, J. M., Palacio Acosta, C. A., Valencia, J. G., Montoya, G. J., Arango Viana, J. C., Nieto, O. C., . . . Ruiz-Linares, A. (2011). Exploring epistasis in candidate genes for antisocial personality disorder. [Research Support, Non-U.S. Gov't]. Psychiatric genetics, 21(3), 115-124. doi: 10.1097/YPG.0b013e3283437175

The work that is sent to this journal must be original, not published or sent to be published elsewhere; and if it is accepted for publication, authors will agree to transfer copyright to International Journal of Psychological Research. 

To give up copyright, the authors allow that, International Journal of Psychological Research, distribute the work more broadly, check for the reuse by others and take care of the necessary procedures for the registration and administration of copyright; at the same time, our editorial board represents the interests of the author and allows authors to re-use his work in various forms. In response to the above, authors transfer copyright to the journal, International Journal of Psychological Research. This transfer does not imply other rights which are not those of authorship (for example those that concern about patents). Likewise, preserves the authors rights to use the work integral or partially in lectures, books and courses, as well as make copies for educational purposes. Finally, the authors may use freely the tables and figures in its future work, wherever make explicit reference to the previous publication in International Journal of Psychological Research. The assignment of copyright includes both virtual rights and forms of the article to allow the editorial to disseminate the work in the manner which it deems appropriate. 

The editorial board reserves the right of amendments deemed necessary in the application of the rules of publication.